3rd Party Lab Tested
Clinically studied doses, in exactly the right combination, for an effective and safe amount with every dose.
Precisely engineered to work with your innate biological defenses
PEA (Palmitoylethanolamide) is an endogenous fatty acid amide, a class of bioactive lipid mediators formed when a fatty acid is biochemically bonded to an amine.
This structural modification distinguishes PEA from ordinary dietary fats, enabling it to act as a cell-to-cell communicator that facilitates biological adaptations to physiological and environmental stressors.
PEA demonstrates the capacity to influence the endocannabinoid system, organically supporting the healthy activity of signaling molecules across the brain, nervous system, and immune network.
It also plays a role in activating the nuclear receptor PPAR-α (Peroxisome Proliferator-Activated Receptor alpha), which regulates gene expression and helps “dial down” excessive inflammatory cascades.
GenuinePurity® Liposomal PEA is designed to work with your natural defense systems, featuring high-grade PEA encased within a plant-derived phospholipid complex to enhance cellular uptake for sustained support.
Health Benefits
Health Benefits
Ingredients
Ingredients
Dosage
Dosage
Each capsule of Liposomal PEA provides you with clinically studied doses, in exactly the right combination, to give you an effective and safe amount with every dose.
Pure, Authentic, Natural Ingredients
GenuinePurity® Liposomal PEA Engineered For Biological Alignment
“A bioactive lipid mediator with anti-inflammatory, analgesic, and neuroprotective properties”1ScienceDirect
Numerous scientific studies indicate that PEA (Palmitoylethanolamide) serves as an influential cellular signaling molecule, helping connect the complex web of physiological systems that sustain life.
In fact, clinical evidence suggests that PEA may be associated with calm inflammatory responses, neural tissue integrity, stable nervous system function, sustained cellular homeostasis, and healthy aging.
Though it’s endogenously produced in small quantities and available in trace amounts in some dietary sources, such as egg yolks, soybeans, and peanuts, PEA is poorly water-soluble, limiting its impact.
The fatty acid amide’s lipophilic nature means it doesn’t readily dissolve in the aqueous environment of the human gut, leading to low dispersion, reduced contact with absorptive surfaces, and inefficient delivery.To get around this “bottleneck” GenuinePurity® Liposomal PEA deploys an advanced delivery system that uses plant-derived phospholipids to support the structural integrity of the bioactive molecules as they pass through the gut, then aligns with internal cellular membrane biology to help promote efficient uptake.
- Non-GMO
- Vegetarian Capsules
- Enhanced Bioavailability
- Scientifically Studied Dose
- No Unnecessary Additives
Neuroinflammatory Balance & Brain Support
“PEA can ameliorate neuroinflammation”2 Neuroscience Letters
PEA has become increasingly recognized for its capacity to support a balanced neuroimmune environment. Within the central nervous system, immune cells such as microglia and mast cells regulate protective responses to physiological stress. However, when overactive, they can disrupt optimal neural function.
PEA activates the nuclear receptor PPAR-α, which influences gene expression involved in inflammatory signaling pathways. In doing so, it’s believed that PEA has a calming effect, helping to modulate microglial activity and support mast cell stability, thereby promoting a controlled neural environment that can facilitate continued brain health.
Nervous System Resilience & Defense
“PEA not only exerts anti-inflammatory and analgesic effects but may also promote the restoration of the structure and function of the nervous system”3 - PubMed Central
The nervous system operates in constant dialogue with the immune system, relying on precisely regulated cellular signaling to maintain stability. When inflammatory mediators accumulate near nerve tissue, they can heighten neural sensitivity and disrupt normal communication pathways, potentially impairing overall function.
PEA operates at this critical juncture of immune and neural activity. Research reveals that the bioactive lipid mediator helps regulate mast cell behavior, limiting the release of the inflammatory compounds that could overstimulate nearby nerve endings. In addition, PEA indirectly supports endocannabinoid tone, helping promote signaling for calm and stress modulation in support of healthy nervous system function.
Calm Inflammatory Responses & Resolution
“PEA can downstream several genes involved in the inflammatory response”4 - MDPI
Inflammation is an essential component of the body’s defense strategy. However, effective health depends on the ability to resolve inflammatory activity once a challenge has passed. Emerging scientific evidence highlights the importance of this resolution phase, the time in which tissues are guided back toward equilibrium and normal function.
PEA exerts a regulatory influence by activating PPAR-α, a receptor that’s involved in modulating inflammatory gene expression. Through this mechanism, PEA contributes to the production of immune signaling molecules that promote a balanced inflammatory environment, helping oversee efficient inflammatory resolution to favor recovery, adaptation, and long-term tissue health.
Cellular Homeostasis & Stress Adaptation
“PEA supplementation may enhance physiological resilience to stress”5 - Frontiers
Cells are constantly adjusting to internal and external stressors, relying on intricate signaling networks to maintain stability and functional health. Notably, under significant cellular strain, the body naturally synthesizes PEA on demand. This suggests it has an adaptive role in sustaining physiological equilibrium.
As a bioactive lipid mediator, PEA participates in communication pathways linking the immune, neural, and metabolic systems. It activates receptors needed to support healthy cellular stress responses, helping to foster stable inflammatory regulation while promoting balanced adaptations. This enables cells to respond efficiently to challenges without drifting into dysfunctional states.
Healthy Aging & Cognitive Longevity
“Recent findings support the hypothesis of its [PEA] use in brain aging”6 - Brain Science
Healthy aging is closely tied to the body’s ability to regulate inflammation, adapt to stress, and maintain coordinated cellular signaling over the long haul. Chronic low-grade inflammatory activity, sometimes called “inflamaging” is increasingly recognized as a contributor to age-related physiological decline.
PEA naturally interacts with several pathways involved in immune responses and modulation of cellular stress, especially in the brain, positioning it as a crucial molecule for long-term biological stability. And some evidence suggests that endogenous PEA production may decline with age.
Supplementing with GenuinePurity® Liposomal PEA can help maintain a robust cellular signaling capacity, reinforcing processes associated with balanced neuroinflammatory responses, nervous system function, and cellular resilience, supporting healthy aging and cognitive longevity.
GenuinePurity® Liposomal PEA The Precision Delivery Difference
Many standard PEA powders and supplements use relatively large crystals that dissolve slowly, remain aggregated, and move through the gut less efficiently.
GenuinePurity® Liposomal PEA is engineered to be better, featuring an advanced delivery system that utilizes plant-based liposomes to support improved dispersion, absorption, and membrane affinity.
Tiny liposomal structures equipped with phospholipid bilayers help more intact PEA molecules reach the small intestine, where they can be made available in the bloodstream.
From there, these liposomal structures derived from sunflower lecithin effectively biomimic endogenous structures, promoting interconnectivity with cellular membranes.
By fostering membrane-level interactions, our advanced delivery system enhances diffusion, thereby helping to increase molecular bioavailability in support of dynamic health benefits.
The GenuinePurity® Standard
At GenuinePurity®, we blend the world's best ingredients with the latest scientific advances to supply you with potent, naturally sourced health supplements. That’s why thousands of men and women around the globe have come to rely on us.
Like all our supplements, GenuinePurity® Liposomal PEA was crafted by our team of seasoned experts, who have over a quarter-century of experience designing high-grade formulas that simply get the job done.
So, if you’re interested in supporting neuroinflammatory balance, nervous system resilience, cellular equilibrium, and healthy aging processes, look no further. Don’t settle for anything but the best. GenuinePurity® Liposomal PEA is expertly formulated to meet your needs.
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- https://www.sciencedirect.com/science/article/pii/S2666354624002059
- https://www.sciencedirect.com/science/article/pii/S0304394022002051
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12358156/
- https://www.mdpi.com/2218-1989/11/9/592
- https://pmc.ncbi.nlm.nih.gov/articles/PMC12491018/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7408069/#:~:text=All%20these%20data%20support%20the%20hypothesis%20of,and%20slow%20down%20brain%20aging%20in%20humans.
